Dominique Langin Selected Research

Sterol Esterase (Hormone-Sensitive Lipase)

6/2019	[An unexpected partnership in fat cells: hormone-sensitive lipase and the transcription factor ChREBP jointly control insulin-sensitivity].
1/2019	Interaction between hormone-sensitive lipase and ChREBP in fat cells controls insulin sensitivity.
9/2015	Primary defects in lipolysis and insulin action in skeletal muscle cells from type 2 diabetic individuals.
4/2013	High-fat diet-mediated lipotoxicity and insulin resistance is related to impaired lipase expression in mouse skeletal muscle.
12/2010	Skeletal muscle lipase content and activity in obesity and type 2 diabetes.
6/2007	The role of neutral lipases in human adipose tissue lipolysis.
10/2006	Importance of TNFalpha and neutral lipases in human adipose tissue lipolysis.
10/2004	The testicular form of hormone-sensitive lipase HSLtes confers rescue of male infertility in HSL-deficient mice.

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.

Realize the full power of the drug-disease research graph!

Dominique Langin Research Topics

Disease

50	Obesity 01/2022 - 04/2003
41	Insulin Resistance 01/2022 - 02/2002
29	Weight Loss (Weight Reduction) 01/2022 - 02/2002
12	Body Weight (Weight, Body) 12/2020 - 12/2005
11	Type 2 Diabetes Mellitus (MODY) 01/2022 - 04/2003
7	Overweight 01/2021 - 09/2013
7	Inflammation (Inflammations) 01/2019 - 01/2013
5	Metabolic Syndrome (Dysmetabolic Syndrome X) 01/2019 - 02/2004
4	Fibrosis (Cirrhosis) 12/2016 - 01/2014
3	Neoplasms (Cancer) 06/2021 - 11/2008
3	Hypertrophy 01/2021 - 01/2014
3	Hyperinsulinism (Hyperinsulinemia) 11/2009 - 04/2003
2	Non-alcoholic Fatty Liver Disease 01/2020 - 01/2016
2	Cachexia 05/2014 - 11/2008
2	Glucose Intolerance 04/2013 - 02/2012
1	Mitochondrial Diseases (Mitochondrial Disease) 08/2019
1	Cardiovascular Diseases (Cardiovascular Disease) 01/2019
1	Burns 01/2018
1	Prediabetic State (Prediabetes) 01/2018
1	Fibrosarcoma 09/2015
1	Hyperplasia 01/2015
1	Endotoxemia 05/2014

Drug/Important Bio-Agent (IBA)

18	Insulin (Novolin)FDA Link 01/2021 - 02/2004
17	Glucose (Dextrose)FDA LinkGeneric 01/2022 - 06/2004
14	LipidsIBA 01/2021 - 04/2003
13	Proteins (Proteins, Gene)FDA Link 12/2017 - 02/2002
11	Triglycerides (Triacylglycerol)IBA 01/2021 - 10/2006
11	Fatty Acids (Saturated Fatty Acids)IBA 01/2019 - 01/2006
10	Messenger RNA (mRNA)IBA 01/2018 - 06/2004
9	LeptinIBA 12/2017 - 04/2003
8	Sterol Esterase (Hormone-Sensitive Lipase)IBA 06/2019 - 10/2004
7	Transcription Factors (Transcription Factor)IBA 06/2019 - 02/2002
7	Lipase (Acid Lipase)FDA Link 01/2019 - 06/2007
7	AdiponectinIBA 10/2013 - 12/2003
5	EnzymesIBA 08/2019 - 09/2005
5	CarbohydratesIBA 01/2018 - 02/2010
4	RNA (Ribonucleic Acid)IBA 01/2021 - 06/2007
4	AdipokinesIBA 01/2019 - 10/2006
3	Nonesterified Fatty Acids (NEFA)IBA 06/2021 - 10/2006
3	Biomarkers (Surrogate Marker)IBA 01/2019 - 09/2005
3	DiglyceridesIBA 04/2013 - 09/2009
3	CatecholaminesIBA 01/2012 - 11/2005
2	Oleic Acid (Oleate)IBA 12/2021 - 06/2021
2	Peroxisome Proliferator-Activated Receptors (PPAR)IBA 01/2019 - 06/2013
2	CytokinesIBA 01/2019 - 11/2009
2	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 01/2019 - 10/2006
2	Natriuretic PeptidesIBA 01/2018 - 12/2015
2	Branched-Chain Amino AcidsIBA 09/2017 - 01/2011
2	Dietary Fats (Dietary Fat)IBA 09/2017 - 01/2012
2	Pharmaceutical PreparationsIBA 01/2016 - 06/2006
2	CollagenIBA 06/2015 - 01/2014
2	Thioctic Acid (Lipoic Acid)IBA 03/2015 - 10/2014
2	AntioxidantsIBA 03/2015 - 10/2014
2	LigandsIBA 05/2014 - 04/2009
2	Acute-Phase Proteins (Acute-Phase Protein)IBA 11/2013 - 02/2012
2	Retinol-Binding Proteins (Retinoid Binding Proteins)IBA 10/2013 - 06/2007
2	Interleukin-8 (Interleukin 8)IBA 06/2013 - 11/2009
2	Dietary ProteinsIBA 05/2012 - 01/2012
2	C-Reactive ProteinIBA 02/2012 - 07/2009
2	Interleukin-10 (Interleukin 10)IBA 11/2009 - 08/2005
2	Plasminogen Activator Inhibitor 1IBA 11/2009 - 08/2004
2	HydrolasesIBA 09/2009 - 10/2004
2	CalciumIBA 10/2006 - 12/2005
1	Pyruvate CarboxylaseIBA 01/2022
1	Vascular Endothelial Growth Factor Receptor-3 (Flt 4)IBA 06/2021
1	Vascular Endothelial Growth FactorsIBA 06/2021
1	CholesterolIBA 01/2021
1	Apolipoproteins MIBA 01/2019
1	Niacin (Nicotinic Acid)FDA LinkGeneric 01/2019
1	MicroRNAs (MicroRNA)IBA 01/2019
1	Protein Isoforms (Isoforms)IBA 01/2019
1	HDL CholesterolIBA 01/2019
1	Blood Glucose (Blood Sugar)IBA 01/2018
1	Guanylate Cyclase-Coupled ReceptorsIBA 01/2018
1	ProteomeIBA 12/2017
1	Phosphoprotein Phosphatases (Phosphatases, Protein)IBA 09/2017
1	Aromatic Amino Acids (Aromatic Amino Acid)IBA 09/2017
1	Perilipin-5IBA 12/2016
1	Glycerol (Glycerine)FDA LinkGeneric 06/2016
1	Intercellular Signaling Peptides and Proteins (Growth Factors)IBA 01/2015
1	9-tetradecenoic acidIBA 01/2015
1	Unsaturated Fatty Acids (Polyunsaturated Fatty Acids)IBA 12/2014
1	Pioglitazone (Actos)FDA Link 07/2014
1	PrebioticsIBA 07/2014
1	Sucrose (Saccharose)IBA 06/2014
1	AntibodiesIBA 05/2014
1	Toll-Like Receptor 4IBA 05/2014
1	LipopolysaccharidesIBA 05/2014
1	Tissue Inhibitor of MetalloproteinasesIBA 03/2014
1	Phenylephrine (Neo-Synephrine)FDA LinkGeneric 01/2014
1	Transforming Growth Factors (Transforming Growth Factor)IBA 01/2014
1	Cyclic GMP-Dependent Protein Kinases (Protein Kinase G)IBA 01/2014
1	3- (4- (4- ((1- (2- chlorophenyl)ethoxy)carbonyl amino)-3-methyl-5-isoxazolyl) benzylsulfanyl) propanoic acidIBA 01/2014
1	Fibronectins (Fibronectin)IBA 01/2014

Therapy/Procedure

12	Caloric Restriction 01/2022 - 02/2004
3	Glycemic Control 01/2020 - 12/2015
2	Bariatric Surgery 01/2021 - 01/2008
1	Gastric Bypass (Roux-en-Y Gastric Bypass) 01/2021
1	Endurance Training 01/2021
1	Carbohydrate-Restricted Diet (Low Carbohydrate Diet) 08/2017